Fig. 7: Conjunctive tuning to eye movement-related and conventional navigational variables.
From: Mouse entorhinal cortex encodes a diverse repertoire of self-motion signals
a The contribution of each variable to model performance (log-likelihood increase (LLI) in information compared to a mean firing rate model; n = # of cells significantly encoding the variable of interest and at least one other variable; median [1st–3rd quartile], B = 0.65 [0.38–0.86], n = 1319; Bs = 0.26 [.11–0.55], n = 1187; Eh = 0.10 [0.05–0.22], n = 335; Ev = 0.14 [0.05–0.30], n = 231; \(\dot E_h\) = 0.05 [0.02–0.12], n = 237; \(\dot E_v\) = 0.04 [0.02–0.11], n = 132). b Comparison of variable contributions (# of cells as in (a); Χ2 = 1.3e3, P = 5.5e−276, df = 5; Kruskal–Wallis test followed by post hoc Wilcoxon two-sided rank-sum comparisons with α = 0.0033 after Bonferroni correction for multiple comparisons). ***for all significant pairwise comparisons, P < 1.9e−10. Boxplots; box, interquartile range; solid line, median; whiskers, range; outliers plotted separately. c The spike-normalized average log-likelihood increase in information across 10 folds of held-out data for all cells significantly encoding at least one variable (median [1st–3rd quartile]; 0.05 [0.02–0.11], n = 2191). d Joint tuning curves. Labels as in Fig. 3d. Minimum and maximum firing rates shown at top, with warmer colors indicating higher firing rates. Unvisited bins are shown in gray. Only model-derived tuning curves for significantly encoded variables are shown. e For each eye movement-related variable we constructed a two-dimensional “tuning curve profile space”. Within a plot, each circle represents a cell whose tuning curves were projected onto the first two principal components (Methods, Supplementary Fig. 11). Subplots are colored according to whether the cell significantly encoded each additional variable. f Example tuning curves from a subset of cells are shown at the cell’s position in the tuning curve profile space. B, body position; Bs, body speed; Eh, horizontal eye position; Ev, vertical eye position; \(\dot E_h\), horizontal eye velocity; \(\dot E_v\), vertical eye velocity.
