Fig. 4: Associated amino acids in the HLA-DQ heterodimer. | Nature Communications

Fig. 4: Associated amino acids in the HLA-DQ heterodimer.

From: GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility

Fig. 4

Two amino acids in HLA-DQB1 and one amino acid in HLA-DQA1 were found to be associated with autoimmune Addison’s disease. A tyrosine at the 30th position and an alanine at the 57th position of HLA-DQB1 (top) and an arginine at the 52nd position of HLA-DQA1 (bottom) have been marked in orange. To visualize the binding pocket, a peptide ligand (gliadin) from the original crystal structure has been marked in pink.

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