Fig. 6: T-cell regulation and AAD GWAS associated regions. | Nature Communications

Fig. 6: T-cell regulation and AAD GWAS associated regions.

From: GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility

Fig. 6

a Graphic representation of selected aspects of T-cell regulation, with gene products implicated by GWAS association proximity in red (antigen-presenting cell, APC). b AIRE activity in medullary thymic epithelial cell (mTEC), promoting expression of tissue-restricted antigens (TRAs) for the education of T cells.

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