Fig. 3: Power calculations using MAST with a random effect for the individual.
From: A practical solution to pseudoreplication bias in single-cell studies
Power curves for various, but likely, single-cell scenarios using MAST with a random effect for individual. Fold-change is simulated by multiplying the global mean gene expression values by the fold-change value for one group. All power is computed at α = 0.05. a Differences in power when sample sizes range between 5 individuals per group to 100 when the number of cells per individual is held constant at 250. b–d Differences in power when increasing the number of cells per individual (100, 250, 500, 1000) for 10, 20, and 50 individuals per group, respectively. Additional power curves are supplied in the supplementary material.
