Fig. 1: The Zα domain of ADAR1p150 binds to Z-RNA.

a Domain organization of ADAR1: Zα and Zβ are structurally homologous helix-turn-helix DNA-binding domains, RBD stands for double-stranded RNA binding domain. Both isoforms are indicated. b Crystal structure of (CpG)₃ bound to Zα from ADAR1 (PDB ID: 2GXB)²⁵. c Close-up of the RNA-protein interface.