Fig. 6: The binding of Zα to AluSx1Jo resembles both binding to the (CpG)3 RNA and a B-Z DNA junction. | Nature Communications

Fig. 6: The binding of Zα to AluSx1Jo resembles both binding to the (CpG)3 RNA and a B-Z DNA junction.

From: Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions

Fig. 6

a Representative peaks and their perturbations from the Zα 15N-HSQC upon addition of AluSx1Jo. b Differences in peak positions between free Zα, 2:1, 1:1, and 1:2 Zα:AluSx1Jo. Red arrows help show the change in peak positions. c Residues undergoing chemical shift perturbation (CSP) and the CSP magnitudes (Supplementary Fig. 14a) from the 15N-HSQC titration are indicated on a surface plot of Zα (left, plotted on PDB: 2GXB25) and compared to CSPs from titrations of a B-Z DNA junction32 (second from left, PDB: 5ZUO33), the (CpG)3 RNA23 (second from right, PDB: 2GXB25), and the (CpG)3 DNA (23) (right, PDB: 3F21 (41)).

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