Fig. 5: CD39⁺PD-1⁺CD8⁺ T cells have a unique transcriptional signature.

a Hierarchical clustering of significantly differentially expressed genes between sorted CD44⁺CD39⁺PD-1⁺CD8⁺ and CD44⁺CD8⁺ T cells. b Volcano plot comparing transcripts in CD44⁺CD39⁺PD-1⁺CD8⁺ T cells with those in other CD44⁺CD8⁺ T cells sorted from 4T07 breast tumors. The red symbols represent transcripts that are significantly over-expressed in CD44⁺CD39⁺PD-1⁺CD8⁺ T cells, whereas the blue symbols represent significantly under-expressed transcripts. c Heat map showing relative expression of selected transcripts in CD44⁺CD39⁺PD-1⁺CD8⁺ (three top rows) and other CD44⁺CD8⁺ T cells (three bottom rows) identified by differential gene expression analysis. d Gene set enrichment analysis comparing the transcriptional profile to the data published by Goldrath et al.⁸⁰ (left panel) and Savas et al.¹⁹ (right panel).