Fig. 3: Genetic loci showing significant ancestral differences in effect-size estimates for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). | Nature Communications

Fig. 3: Genetic loci showing significant ancestral differences in effect-size estimates for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).

From: Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups

Fig. 3

a Correlation of effect-size estimates for SLE between East Asian (X-axis) and European (Y-axis) populations (r = 0.58, two-sided P-value = 6.52E−11). Disease-associated variants with FDR adjusted CQ-test P-value <0.05 (category 3) are labeled in red, and the variants with CQ-test P-value < 0.05 but FDR adjusted CQ-test P-value ≥0.05 (category 2) are labeled in blue. b, c Forest plots of association from each cohort at the TYK2, PRKCB and PLD4 loci. Diamonds represent the combined estimates of odds ratio (OR) in East Asians (EAS, red) and Europeans (EUR, green) for association with SLE. Standard error bars of OR represent 95% confidence intervals of the estimates. Squares represent OR estimates for rheumatoid arthritis (RA) in EAS (red) and EUR (green) populations. Regional plots for each locus are available in Supplementary Fig. 10. HK, Hong Kong; GZ, Guangzhou; CC, Central China; KR, Korean; BJ, Beijing; MC, Malaysian Chinese; SP, Spanish.

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