Fig. 5: Performance of polygenic risk scores (PRS) calculated by summary statistics from different ancestral groups. | Nature Communications

Fig. 5: Performance of polygenic risk scores (PRS) calculated by summary statistics from different ancestral groups.

From: Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups

Fig. 5

a Performances of PRS are indicated by area under receiver operating characteristic curve (AUC). PRS for individuals from the Guangzhou (GZ) cohort were calculated using summary statistics from ancestry-matched Chinese populations (2618 cases and 7446 controls; red) and European populations (4576 cases and 8039 controls; blue). b Distribution of PRS for SLE cases (blue) and controls (pink) from the GZ cohort. The PRS distribution was estimated using summary statistics from the ancestry-matched Chinese cohorts (upper panel) or from the mismatched European GWAS (lower panel). The optimal threshold for disease risk prediction is indicated by the red vertical line. c Odds ratios (ORs) of disease risk across different PRS groups in the GZ GWAS. The samples from GZ are equally divided into ten groups (n = 259 independent samples in each group) based on PRS estimated from ancestry-matched data. The 1st decile represents the lowest PRS group while 10th decile refers to the group of samples with the highest PRS. ORs and 95% confidence intervals (bars) for each group were calculated by reference to the 1st decile group.

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