Fig. 1: Structure of PLpro from SARS-CoV-2 and comparison with human USP12. | Nature Communications

Fig. 1: Structure of PLpro from SARS-CoV-2 and comparison with human USP12.

From: Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

Fig. 1

A PLpro model showing secondary structure and “thumb-palm-fingers” architecture, with domains and subdomains labeled and active site residues Cys111/His272/Asp286 represented as spheres, zinc ion is in blue. B Model of human USP12 (PDB id: 5K1B48) showing similar fold and domain architecture with active site residues Cys48/His317/Asp333 represented as spheres and zinc ion in blue.

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