Fig. 2: Comparison of dynamic changes of PaO₂/FiO₂ between BEVA (bevacizumab) and control groups.

PaO₂/FiO₂ values in all patients (a), Chinese (b), and Italian (c) groups. The dashed lines represent the baselines; nodes in the lines represent the median values; the lower and upper values of the bar correspond to the 25th and 75th percentiles (Q1 and Q3); the length of the bar represents the interquartile range (IQR); red and blue numbers correspond to the sample sizes (n); numbers on the horizontal lines represent p-values. D-values (the difference values between days 1 or 7 and baseline) of individual patients were utilized for the comparisons between BEVA and control groups of all patients (d), Chinese (e), and Italian (f) patients. The center lines of boxes represent median values; the lower and upper hinges represent Q1 and Q3, the range between which represents IQR; whiskers correspond to the highest or lowest values of non-outlier data (within 1.5 × IQR from the lower or upper hinges); numbers on the horizontal lines represent p-values; red and blue numbers correspond to the sample sizes (n); the red and blue dots represent the data of individual patients. For a–c, p-values were calculated by Wilcoxon matched-pairs signed-rank test. For d–f, p-values were calculated by Wilcoxon signed-rank test. PaO₂/FiO₂ partial arterial oxygen pressure to fraction of inspiration O₂ ratio. p < 0.05 for two-tailed hypothesis tests was considered statistically significant. Source data are provided as a Source Data file.