Fig. 4: QMT detection of single nucleotides. | Nature Communications

Fig. 4: QMT detection of single nucleotides.

From: Combined quantum tunnelling and dielectrophoretic trapping for molecular analysis at ultra-low analyte concentrations

Fig. 4

a Conductance vs time trace for four deoxymononucleotides: dTMP (green), dCMP (orange), dAMP (blue) and dGMP (red). Data were acquired in 1 mM PBS (pH 7.4) containing 100 pM nucleotides, at 50 mV. The gap width was ~1.1 nm. b Scatter plot of the transients for each mononucleotide. c, d Normalised bar chat of the conductance and dwell time for each nucleotide. Mean values are presented as means ± SD, as shown in Supplementary Table 2. ***P < 0.001 (two-tailed P value), determined by Student’s t-test.

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