Fig. 2: STM enhances glycolysis and reduces serine synthesis in macrophages to promote intracellular replication. | Nature Communications

Fig. 2: STM enhances glycolysis and reduces serine synthesis in macrophages to promote intracellular replication.

From: Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Fig. 2: STM enhances glycolysis and reduces serine synthesis in macrophages to promote intracellular replication.The alternative text for this image may have been generated using AI.

a Replication of STM in Pfkfb3 siRNA-treated or control siRNA-treated RAW264.7 cells. b Replication of STM in PFK-15-treated or untreated PMs. c Serine and 3-phosphoglycerate (3PG) levels in PMs infected with live or heat-killed STM for 8 h in serine-depleted RPMI medium. d phgdh mRNA levels in PMs infected with live or heat-killed STM for 8 h in serine-depleted RPMI medium. e Serine and 3PG levels in phgdh-overexpressing (OE:+) or control (OE:−) RAW264.7 cells cultured in serine-depleted RPMI medium. f Serine and 3PG levels in Phgdh siRNA-treated or control siRNA-treated RAW264.7 cells cultured in serine-depleted RPMI medium. g Replication of STM in phgdh-overexpressing or control RAW264.7 cells. h Replication of STM in Phgdh siRNA-treated or control siRNA-treated RAW264.7 cells. i Replication of STM in 5 μM NCT-503-treated or untreated PMs. Data are presented as mean ± SD, n = 3 independent experiments; P values were determined using two-tailed unpaired Student’s t test (a, b, d–i) or one-way ANOVA (c). Source data are included in Source Data file.

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