Fig. 1: Prior strategies and our synthetic design for the synthesis of peptides and proteins with three disulfide bonds. | Nature Communications

Fig. 1: Prior strategies and our synthetic design for the synthesis of peptides and proteins with three disulfide bonds.

From: General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins

Fig. 1

a Oxidative folding under thermodynamic control, main limitations. b Stepwise deprotection and oxidation strategy, main limitations. c Ultrafast high-yielding formation of multiple disulfide bonds via our strategy (PG is abbreviation for protecting group, UV is abbreviation for ultraviolet-light and DSF is abbreviation for disulfiram).

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