Fig. 1: Looming sound-induced freezing-escape defensive behavior.
From: Corticostriatal control of defense behavior in mice induced by auditory looming cues
a Schematic diagram of open field test for sound-induced behavior. A speaker was attached to one of the walls. A nest (green circle) was placed in a corner. Gray and red traces label the movement trajectory before and after presenting (including during) crescendo stimuli respectively for an example animal. Blue dot marks the location of crescendo-triggered freezing. b Illustration of one trial of crescendo stimuli. Right: individual stimulus. c Locomotion speed for the example animal shown in (a). Different behavioral phases are labeled by different colors: freezing (blue), escape (red) and nest time (green). d Movement trajectory of an example animal in response to decrescendo stimuli. Gray: before decrescendo stimuli. Black: during presentation of decrescendo stimuli. e Illustration of decrescendo stimuli. f Locomotion speed for the animal shown in (d). g, Color-coded behavioral outcome in response to crescendo (left) and decrescendo (right) stimuli in 10 mice. h Comparison of crescendo and decrescendo induced freezing duration. Data points for the same animal are connected with a line. ***p = 1.033 × 10−4, two-sided paired t test, t = 5.669, n = 10 mice. i Comparison of normalized top speed. **p = 0.003, two-sided paired t test, t = 4.059, n = 10. j Comparison of nest time. ***p = 6.103 × 10−5, two-sided paired t test, t = 5.126, n = 10. Data are presented as mean ± s.e.m. for (h–j). The center presents the mean value and the bar represents s.e.m.
