Fig. 3: Manhattan plot of gastroesophageal reflux disease (GORD), peptic ulcer disease, GORD and corresponding medications (PG₊M) and irritable bowel syndrome (IBS) for SNPs associated P < 1.0E−4 from BOLT-LMM association test.

a GORD: SNPs highlighted with orange squares are genome-wide statistically significant (P < 5.0E−8) independent loci, which correspond to the orange squares in b. SNPs highlighted with yellow represent loci that have not previously been reported to be associated with GORD. b PG₊M: SNPs highlighted with red diamond are independent loci with P < 5.0E−8. Only two of eight SNPs associated with peptic ulcer disease (highlighted with green triangles) are with P < 1.0E−5 in PG₊M and all the SNPs associated with GORD (highlighted with orange squares) have P < 1.0E−5 in PG₊M. SNPs highlighted with yellow represent loci that have not previously been reported to be associated with GORD. c IBS: SNPs highlighted with red diamond are independent loci with P < 5.0E−8. The blue dot is for rs10512344 that has been reported associated with female IBS in UKB previously released data²³. The IBD Manhattan plot is found in Supplementary Fig. 2.