Fig. 5: Analyses of partitioning SNP-based heritability by different annotations. | Nature Communications

Fig. 5: Analyses of partitioning SNP-based heritability by different annotations.

From: GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression

Fig. 5

a SNP-based heritability enrichment analysis for each digestion phenotype partitioned by cell type groups annotated by histone marks. The dashed line represents the Bonferroni corrected significance threshold (0.05/(53 * 5 + 5 * 5)). b SNP-based heritability enrichment analysis for PG+M and IBD partitioned by cell types annotated using cell-type specific gene expression data given the results from a. The dotted lines represent the Bonferroni correction threshold (P < 0.05/(205*2)). c SNP-based heritability enrichment analysis for GORD, PG+M, and IBS partitioned by cell types annotated using fine-scale GTEx brain gene expression data from 13 brain regions selected given the central nervous system enrichment results of these three phenotypes from a. The dashed line represents the Bonferroni correction threshold (P < 0.05/(13*3)).

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