Table 1 Full-sibling relative risk and heritability estimation for PUD, GORD, IBS, and IBD.

From: GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression

 

Digestion phenotypes

PUD

GORD

IBS

IBD

N case:N control*

16666:439661

54854:401473

29524:426803

7045:449282

N case/(N case + N control)

0.037

0.120

0.065

0.015

No. of male case:No. of female case

9641:702s5

24841:30013

7981:21543

3432:3613

No. of male control:No. of female control

199156:240505

183956:217517

200816:225987

205365:243917

Odds of being male case/Odds of being female case

0.048/0.029

0.135/0.138

0.040/0.095

0.017/0.015

Male:female odds ratio for being case

1.66

0.98

0.42

1.13

No. of full-sibling pairs where both proband and full-sibling are cases

104

940

236

38

No. of full-sibling pairs where only the proband is a case

1460

4530

2682

630

Full-sibling relative risk (95% confidence interval)

1.82 (1.51–2.19)

1.43 (1.35–1.52)

1.25 (1.11–1.41)

3.68 (2.70–5.02)

Heritability (95% confidence interval)†

0.28 (0.18–0.37)

0.28 (0.23–0.33)

0.12 (0.05–0.19)

0.49 (0.36–0.64)

  1. *The number for the cases and controls of each digestion phenotypes are from the whole UK Biobank individuals with European ancestry, i.e., related individuals are included.
  2. †The corresponding lower and upper values of 95% confidence interval (CI) for risk in full-sibling were used to calculate the 95% CI for heritability estimation.
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