Fig. 4: Representative molecular functions of the candidate genes depicting overrepresentation of four major signaling pathways critical for regulating hypoxia tolerance.
From: Multiple mechanisms drive genomic adaptation to extreme O2 levels in Drosophila melanogaster
a Rho guanyl-nucleotide exchange factor activity (pink area, p-value = 5.65E-06), b glutamate receptor activity (purple area, p-value = 2.31-06), c PI3K activity (green area, p-value = 2.24E-06) and d Vascular endothelial growth factor (VEGF) signaling (orange area, p-value = 4.45E-06). The p-value was calculated using Hypergeometric test and corrected using Benjamini & Hochberg False Discovery Rate (FDR). A p-value < 0.05 as significant level.
