Fig. 5: S-LDXR results for 53 specifically expressed gene (SEG) annotations for BMI and height. | Nature Communications

Fig. 5: S-LDXR results for 53 specifically expressed gene (SEG) annotations for BMI and height.

From: Population-specific causal disease effect sizes in functionally important regions impacted by selection

Fig. 5

a We report estimates of the enrichment/depletion of squared trans-ethnic genetic correlation (λ2(C)) for each SEG annotation for BMI and height. SEG annotations are ordered as in Fig. 4. Error bars denote ± 1.96 × standard error. P-values are obtained from the standard normal distribution. Red stars (⋆) denote two-tailed p < 0.05/53 for each respective trait (p = 8.2 × 10−4 for BMI and p = 3.3 × 10−4 for Height). b We report λ2(C) estimates for height vs. BMI for each SEG annotation. These estimates were moderately correlated (R = 0.35). Annotations are color-coded as in (a). For Pituitary, height λ2(C) is left-shifted by 0.008 and BMI λ2(C) is right-shifted by 0.008 for easier visualization of standard errors. Error bars denote ± 1.96 × standard error. The dashed black line denotes the y vs x line. Numerical results for all 31 diseases and complex traits are reported in Supplementary Data 21.

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