Fig. 5: Study of pubertal development of Wistar and GK rats.
From: The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome
a Percentage of rats with opened vaginas from 4 to 8 weeks of age. Inset shows the mean age of the rats at the vaginal opening. b Evolution of body weight (full line) and of Lee index (dotted line) of Wistar and GK rats between 4 and 12 weeks. p-values are from two-sided Mann–Whitney U tests followed by a post-hoc Bonferroni’s adjustment. c Percentage of rats with vaginal opening in each body weight class. Inset shows the mean weight of rats at vaginal opening. d Percentage of rats at first estrus for each body weight class. Inset shows the mean weight of rats at the time of the first estrus. e Delay between vaginal opening and the first estrus. f Illustration of estrous cycle profiles from the first estrus for 1 Wistar and 2 GK rats. Proestrus–Estrus P–E, Metestrus M, Diestrus D. g Delay between first estrus and the beginning of regular estrous cycles in Wistar and GK rats. h–j Serum levels of Testosterone (h), Delta-4-androstenedione (i), and AMH (j) assessed on 5–12-week-old Wistar and GK rats. Data are represented as box with scatter blot with mean ± SEM (a, c, d insets and e, g), as mean ± SEM (b) or as scatter blot with mean ± SEM (h–j). p-values are from two-sided Mann–Whitney U test for unpaired comparisons (GK vs. Wistar rats). n represents the number of biologically independent animals in each group. Wistar: white, GK: gray. Source data are provided as a Source Data file.
