Fig. 5: Notch2IC regulates genes involved in transcription and homing.
From: Notch2-mediated plasticity between marginal zone and follicular B cells
a Mean fold changes in RNA levels of transcription factors and transcriptional regulators in hCD2+ versus hCD2− cells over all time points after TAM treatment. Fold changes of wild type MZB versus FoB samples are shown as bar graph. b Enrichment plots of GSEA analysis using Klf2-KO gene sets defined by a microarray analysis of Klf2-deficient FoB cells published by Hart and colleagues39. The GSEA shows a significant enrichment of KLF2 target genes at the top and bottom ends in the ranked dataset of hCD2+ (day 14 after TAM) versus hCD2− cells. c Mean fold changes in RNA levels of genes involved in B cell migration and MZ homing. Analysis according to (a). Colored gene names are KLF2 target genes from (b) which are up- (orange) or down- (blue) regulated in the conditional Klf2 knockout.
