Fig. 2: Manhattan plot of GWAS results from 45 clinically-relevant traits.

The chromosomal position of genetic variants (N = 7,880,618) is plotted against –log10 (P). Analysis was performed using linear mixed models correcting for age, sex, population principal components and relatedness. The red horizontal line represents the threshold for genome-wide significance (P < 5.0 × 10−8).