Fig. 3: Comparison of allele frequency and linkage disequilibrium patterns.
Example of multiple distinct signals identified at loci associated with clinically-relevant traits. a Regional association plots for total bilirubin (Tbil) locus on chromosome 2 and (b) the prothrombin time (PT) locus on chromosome 13. The plots show chromosomal positions of SNPs plotted against –log10 (P). Multiple distinct signals are shown as red circles, blue lines represent recombination rate. c–f Comparison of allele frequency and linkage disequilibrium for the distinct signals between QGP and European population (c and d) or between QGP and East Asian populations (e and f) for the Tbil and PT loci. Linkage disequilibrium patterns between the distinct signals from QGP data are shown below the red diagonal boxes and those from European (c, d) or East Asian (e, f) populations are shown above the diagonal red boxes. Grayed areas indicate monomorphic SNPs. MAF indicates minor allele frequency from QGP, European (CEU) or East Asian (EAS) populations.
