Fig. 8: Differences in MHC-E restricted activity of secondary lymphoid tissue NK cells between natural and heterologous hosts. | Nature Communications

Fig. 8: Differences in MHC-E restricted activity of secondary lymphoid tissue NK cells between natural and heterologous hosts.

From: SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity

Fig. 8

a, b HLA-E dependent cytotoxic activity of NK cells isolated before infection and in chronic infection from LN of MAC (orange), and AGM (blue). K562-E*0101 were loaded or not with peptides. Uninfected MAC are indicated in orange squares and uninfected AGM in blue triangles. SIV-infected animals are indicated in black. The black line indicates the median and error bars the interquartile range. Each symbols represents a unique monkey. For Groups comparisons two-sided Wilcoxon signed-rank test with Bonferroni correction were used (n = 3). P values of less or equal to 0.05 were considered statistically significant. Asterix indicate significant change when compared to the base line. Exact P value are provided on the graphs. c, d HLA-E dependent cytotoxic activity of NK cells isolated from spleen of chronically infected c MAC and d AGM against distinct SIV ENV peptides. The black line indicates the median and error bars the interquartile range. Each symbols represents a unique monkey. For Groups comparisons two-sided Wilcoxon signed-rank test with Bonferroni correction were used (n = 7). P values of less or equal to 0.05 were considered statistically significant. Asterix indicate significant change when compared to the base line. Exact P values are provided on the graphs.

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