Fig. 1: Structure of initiation of RING-anchored ubiquitin chain elongation. | Nature Communications

Fig. 1: Structure of initiation of RING-anchored ubiquitin chain elongation.

From: RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination

Fig. 1

a Side and top view of the Ub-R:Ube2N~Ub:Ube2V2 structure (Ub-R, Ub in red, R in blue, Ube2N~Ub, Ube2N in green, Ub in orange, and Ube2V2 in teal). Chains drawn as cartoon represent the asymmetric unit. b The canonical model of initiation of RING-anchored ubiquitin chain elongation. c Schematic cartoon, representing the canonical model of RING-anchored ubiquitin chain elongation shown in b. Symmetry mates are denoted by ′ next to the label. Ub ubiquitin, Ub-R ubiquitin-RING.

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