Fig. 6: TRIM protein assembly on viruses. | Nature Communications

Fig. 6: TRIM protein assembly on viruses.

From: RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination

Fig. 6

Cartoon models of the assembly of TRIM5 (a, b) and TRIM21 (c, d) on viral capsids. a Shown is the hexagonal assembly of TRIM5 on HIV-1 capsid as imaged by cryo-electron tomography48. c Assembly of TRIM21:antibody complexes on adenovirus capsid (adenoviral measurements are based on 6B1T68). b, d Cartoons visualizing how the TRIM protein assembly on the viral capsid enables the formation of the catalytic RING topology. R RING, B Box, CC coiled-coil, PS PRYSPRY, Ub ubiquitin.

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