Fig. 4: Quantification of antigen-specific CD4+ and CD8+ T cell responses.
From: Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19
a Representative staining of AIM markers (CD25, OX-40) on CD4+ Tmem cells (CD3+ CD4+ CD8-CD45RA-CXCR5-) or AIM markers (CD69, CD137) on CD8+ Tmem cells (CD3+ CD8+ CD4-non-naïve) after stimulation with vehicle, S1 or S2 peptide pools in an uninfected individual. b Representative staining of AIM markers on CD4+ Tmem cells in longitudinal samples from 1 participant (top row, day 33; middle row, day 61; bottom row, day 143). c Representative staining of AIM markers on CD8+ Tmem cells in longitudinal samples from 1 participant (top row, day 41; middle row, day 85; bottom row, day 120). d Longitudinal changes in the frequency of total S (S1 + S2 pool responses after background subtraction)-specific responses among CD4+ Tmem, cTFH, and CD8+ Tmem subsets (n = 31). e Comparison of S-specific T cell responses at the earliest and latest timepoint available for each individual (n = 31). Statistics assessed by two-tailed Wilcoxon test. Source data are provided as a Source Data file.
