Fig. 5: Modelling of concomitant immune responses after COVID-19.
From: Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19
a Rates of decay of serological neutralisation activity, ACE2 binding inhibition, and S-specific IgG, IgM and IgA following recovery from SAR-CoV-2 infection. Baseline levels are set to 100% of that of the mean responses at visit 1 (median 40 days, shown in Fig. 1a). b Fitted Growth and decay rates for S-specific memory T cell and B cell frequencies in PBMC. The neutralising antibody decay curve (black line) is shown for comparison purposes. c Simulation of elicitation and decay of serological neutralisation activity in 1000 individuals based on distributions observed in our SARS-CoV-2 convalescent cohort. The simulation was repeated 1000 times to estimate the proportion of individuals maintaining a neutralisation titre above 1:40 across multiple simulations (median and 95% confidence intervals shown in red). Source data are provided as a Source Data file.
