Fig. 4: TRAPed V1 neurons selective for the conditioned stimulus are reactivated in post-conditioning sleep. | Nature Communications

Fig. 4: TRAPed V1 neurons selective for the conditioned stimulus are reactivated in post-conditioning sleep.

From: Causal role for sleep-dependent reactivation of learning-activated sensory ensembles for fear memory consolidation

Fig. 4

a cfos::tdTom mice had recombination induced to a specific angle (X°). Eleven days later, they were cue conditioned to either the same angle as induction (X°; n = 7 mice) or an alternate angle (Y°; n = 4 mice). All mice were allowed 4.5 h of post-conditioning ad lib sleep prior to tissue harvest. b, c Representative images showing overlap of cFos expression (cyan) with tdTomato (red). The boxed region is magnified as an inset with an arrow indicating an overlapping neuron. Expression of cFos in tdTomato-labeled cells was greater for mice conditioned to the same orientation used for TRAP labeling (*p = 0.0106 [t = 2.633, DF = 63], nested t test). d, e Densities of tdTomato+ and cFos+ neurons were similar in X° and Y°-conditioned mice. Values indicate mean ± SEM.

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