Fig. 2: Substrate scopes of aryl bromides and ene-yne-ketones.

[a] Reaction conditions: 1 (0.1 mmol, 1.0 equiv), 2 (0.2 mmol, 2.0 equiv), [Pd(Cl(allyl)]₂ (5 mol%), ^tBuXphos (30 mol%), NaOAc (3.0 equiv), DMF (1 mL), under N₂, 100 °C, 4 h. Yields of isolated products. [b] The reaction was run in 2.0 mmol scale.