Fig. 4: Substrate scopes of complex aryl bromides from modified drug molecules.

[a] Reaction conditions: 1k–1p (0.1 mmol, 1.0 equiv), 2a or 4c (0.2 mmol, 2.0 equiv), [Pd(Cl(allyl)]₂ (5 mol%), ^tBuXphos (30 mol%), NaOAc (3.0 equiv), DMF (1 mL), under N₂, 100 °C, 4 h. Yields of isolated products.