Fig. 5: Derivatization of the Si-stereogenic heterocycles. | Nature Communications

Fig. 5: Derivatization of the Si-stereogenic heterocycles.

From: Enantioselective construction of six- and seven-membered triorgano-substituted silicon-stereogenic heterocycles

Fig. 5

Reaction conditions: a [Rh(cod)Cl]2 (2 mol%), (racemic)-Josiphos L1 (4 mol%), vinyl ether (2.0 equiv), toluene, 60 °C, 12 h, de = diastereomic excess. b Pt(dvds) (10 µL, 0.1 M in xylene), 1,2-diphenylacetylene (2.0 equiv), toluene, 40 °C, 12 h. c Pd(tBu3P)2 (2 mol%), 4-iodoanisole (2.0 equiv), K3PO4 (3.0 equiv), NMP, rt, 12 h. d [Rh(cod)Cl]2 (2 mol%), (racemic)-Josiphos L1 (4 mol%), acetone (2.0 equiv), toluene, 60 °C, 12 h. e [Rh(cod)Cl]2 (2 mol%), (racemic)-Josiphos L1 (4 mol%), vinyl ferrocene (2.0 equiv), toluene, 60 °C, 12 h. X-ray crystallographic analysis of 6a allowed to determine the absolute configuration; and configurations of the products 4 were assigned by analogy.

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