Fig. 1: Overview of CookHLA.
From: Accurate imputation of human leukocyte antigens with CookHLA
a In the reference panel, CookHLA encodes HLA alleles as binary markers. b CookHLA repeats imputation while embedding a binary marker set into the middle position of each polymorphic exon. After the repeated imputations, CookHLA performs consensus calls by merging posterior probabilities. c CookHLA adaptively learns the data-specific genetic map within the MHC from the data.
