Fig. 1: The principle of SL and SDL.
For gene A and B, if only one gene has a mutation or an overexpression in the tumor cell, the tumor cell is still alive. However, the pharmacological intervention of the partner gene will result in SL interaction in tumor cell which has a loss-of-function mutation of the tumor suppressor gene (TSG) (a). In addition, the pharmacological intervention of the partner gene will result in SDL interaction in tumor cell which has a gain-of-function mutation or an overexpression of the oncogene (b). The red star denotes a mutation. The thicker arrow denotes an overexpression. The cross line denotes a pharmacological intervention.
