Fig. 3: Characterisation of the myeloid cells in PDAC.
A Characterisation and quantification of the myeloid cell population found in the scRNA-Seq analysis of PDAC tumours from Peng et al. Data presented as mean values ± SEM. B Heatmap highlighting the markers characterising each myeloid population. C Expression of Siglec receptors in the different myeloid populations. D Clustering of patients using the presence of myeloid populations distinguishes patient groups. E Correlation between the moDC and moMac as a % of total myeloid cells. Spearman correlation coefficient, p value and 95% confidence interval are depicted in the figure. F Analysis of the differentiation of monocytes towards dendritic cells or macrophages using diffusion map (using the R package destiny) and pseudotime (slingshot). G Survival analysis based on a moMac/moDCs ratio Score in bulk transcriptomic data using the Log-rank test. moMac/moDC ratio Score was defined as the difference between a moMac and a moDCs Score (ScoremoMac − ScoremoDCs). Top and bottom thirds were used to define samples enriched in moMac or moDCs, respectively. Data set shown: E-MTAB-6138.
