Fig. 5: Both human and mouse GITR can form higher-order structures.
From: Structures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions
a mGITR can form linear planar networks when interacting with mGITRL. b In the crystal structure, hGITRL forms tetrameric trimer complexes (four hGITRL trimers interacting with four hGITR pairs). c If modeled as a planar network on the surfaces of opposing cells, human GITR–GITRL creates branching hexamers consisting of six ligand trimers and six receptor trimers. GITRL depicted in orange, GITR in blue.
