Fig. 8: Comparison of TNF–TNFR complexes highlights minimal GITR interface.
From: Structures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions
a hGITR–hGITRL (380 Å2 interface). b h4-1BB–h4-1BBL (6MGP, 950 Å2 interface). c hTNFa–hTNFR2 (3ALQ, 1330 Å2 interface). d mAPRIL–hTACI (1XU1, 880 Å2 interface). Interactions are shown for surfaces of trimeric ligands (orange, tan, and olive) and receptors (light blue, deep teal, and marine), with single receptor removed to show receptor–ligand interface (purple).
