Fig. 8: Dual feedback governs transcriptional and post-translational regulation of VHP-1.
From: Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress
Mechanical stress via blunt force trauma activates KGB-1, which leads to the transcriptional upregulation of vhp-1 and repression of math-33. VHP-1 is stabilized by MATH-33 and, in turn, represses KGB-1 activity.
