Fig. 1: Structural domains of the open-state hERG1 channel considered in this work (PDBID: 5VA2). | Nature Communications

Fig. 1: Structural domains of the open-state hERG1 channel considered in this work (PDBID: 5VA2).

From: Lipid regulation of hERG1 channel function

Fig. 1

a Structural organization of one monomer. The voltage-sensor domain (VSD), the pore domain (PD), and the cytoplasmic domain (CTD) are highlighted in green, blue, and gray cartoons, respectively. The inset displays key residues (licorice representation) of the PD accessible from the VSD–PD interface. The panels b and c show side- and extracellular views, respectively, of the full tetrameric hERG1 structure. Panel d displays the S2 and S4 helices (green cartoons) from one of the VSDs, highlighting key residues (licorice representation) involved in voltage-dependent gating. The C, O, N, and S atoms in a and d are colored in cyan, red, blue, and yellow, respectively.

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