Table 1 Values of IC50 and Hill coefficients calculated from dose-response curves for hERG1 variants.

From: Lipid regulation of hERG1 channel function

hERG1 variant

WTa

B

Y652Aa

F656Ca

M651Ta

F557La

\({\mathrm{IC}}_{50}^{{\mathrm{CER}}6}\) [µM]

22

8

17

385

46

33

|Hill|

0.8

1.1

1.0

0.5

0.9

1.9

Stable levelb

0.3

0.1

0.1

0c

0.4

0.4

  1. aReported for hERG1 isoform A.
  2. bResidual current (IhERG1/Icon) extrapolated at infinite [CER6].
  3. cEstimated value. No clear asymptote was observed even at [CER6] = 500 µM.
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