Fig. 9: Single cell RNA-seq analysis of E17.5 wild-type (WT) and Atoh7-null (MT) cells. | Nature Communications

Fig. 9: Single cell RNA-seq analysis of E17.5 wild-type (WT) and Atoh7-null (MT) cells.

From: Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas

Fig. 9

a Identifies of UMAP clusters of WT and MT retinal cells, including naive RPCs (nRPC), transitional RPCs (tRPC), retinal ganglion cells (RGCs), horizontal and amacrine cells (H&A), photoreceptors (PH). Note there are two transitional RPC clusters, two photoreceptor clusters, and a cluster (?) whose identity needs to be further confirmed. b Feature heatmaps showing genes expressed in transitional RPCs, including Atoh7, Neurog2, Neurod1, and Otx2 in WT and MT retinas. c Feature heatmaps of a set of RGC genes in WT and MT retinas, including Crabp1, Gal, Sncg, and Pou6f2. Crabp1, Gal, and Sncg are downregulated, whereas Pou6f2 is upregulated, in the MT RGCs. Color scales represent natural-log transformed normalized gene expression levels as described in “Methods”.

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