Fig. 8: VPS34 inhibitor reverses the NAFLD protective effects of TRABID. | Nature Communications

Fig. 8: VPS34 inhibitor reverses the NAFLD protective effects of TRABID.

From: VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism

Fig. 8

a Schematic representation of the experimental design to evaluate whether the NAFLD protective effects of TRABID is mediated by VPS34. b The percentage of liver per body weight in indicated mice. Data are mean ± SD from six mice. P-values are determined by one-way ANOVA with Tukey’s post hoc test. c H&E and Oil Red O staining of liver sections taken from indicated mice. Bar, 50 μm. The percentages of area stained positive for Oil Red O were quantified and shown on the right. Data are mean ± SD from six mice. P-values are determined by one-way ANOVA with Tukey’s post hoc test. d, e AST and ALT assays in indicated mice. Data are mean ± SD from six mice. P-values are determined by one-way ANOVA with Tukey’s post hoc test. Source data are provided as a Source Data file.

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