Fig. 6: Humoral responses in ART-suppressed tissues.
From: Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques
A SIVmac23H Env titers from multiple gut and LTs from a subset of SIV-infected monkeys from both the Late ART (n = 3 for mesenteric LN and n = 4 for all other tissues) and Early ART studies (n = 6). The median is shown as a red line and p values reflect two-tailed Mann Whitney U tests. B Linear regression of SIVmac32H Env titers (x axis) and log SIV DNA copies/106 cells (y axis) in the profiled tissues in the Late ART (upper) and Early ART (lower) studies. C The Fc functional profiles of these SIV Env antibodies are shown for the Late ART and Early tissues. Each row in the heat map is a different tissue Fc profile for antibody dependent neutrophil phagocytosis (ADNP), antibody dependent cellular phagocytosis (ADCP), and NK functionality (CD107a/IFN-γ/MIP1β expression). LN, lymph node, Env, Envelope.
