Fig. 2: Microcircuit parameters and associations with macroscale findings.
a A relaxed mean-field model18 was used to predict functional connectivity (FC) from structural connectivity (SC) and to estimate region-specific microcircuit parameters, i.e., recurrent excitation/inhibition Wi and subcortical/external input Ii (left). A global coupling constant G is also estimated. Linear correlations between FC and SC, and empirical and simulated FC are shown (right). Black lines indicate mean correlation and gray lines represent 95% confidence interval across cross validation. b Microcircuit parameters of controls (left) and differences of the parameters between individuals with autism and controls (middle). Linear correlations between t-statistics derived from the multivariate group comparison and the regional changes in microcircuit parameters are reported, constrained to regions showing significant between-group differences in Fig. 1c (right). Source data are provided as a Source Data file.
