Fig. 1: Identification of PDAC CAR target candidates. | Nature Communications

Fig. 1: Identification of PDAC CAR target candidates.

From: Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma

Fig. 1

a Top 50 antigens expressed on the cell surface of PDAC PDX models as determined by flow cytometry-based screening of a 371 monoclonal antibody panel. b Selection of 15 cyclic immunofluorescence images of a representative human PDAC tissue to evaluate co-expression of the marker of interest (MOI) with cytokeratin-positive tumor cells. Images are representative for two cyclic IF runs on two different PDAC specimen. c Flow cytometric analysis of expression for eight target candidates on primary human PDAC samples. Data represent mean ± s.e.m. (n = 7, ****P < 0.0001 determined through two-way ANOVA with Tukey’s test). Scale bar = 100 µm. Source data are provided as a Source Data file.

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