Fig. 1: Loss of aldehyde detoxification is conspicuous in esophageal adenocarcinoma. | Nature Communications

Fig. 1: Loss of aldehyde detoxification is conspicuous in esophageal adenocarcinoma.

From: Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma

Fig. 1

a Geneset enrichment analysis comparing squamous mucosa (SqN, n = 19) and esophageal adenocarcinoma (EAC, n = 21) samples in GSE26886. Five most significantly enriched Gene Ontology v4.0 genesets in squamous mucosa. P values calculated by the permutation test in the GSEA analysis. b Enrichment plot of “oxidoreductase (OR) acting on aldehydes” geneset from a. c Relative expression of candidate ALDH isoenzymes in EAC endoscopic biopsies compared to paired SqT biopsies (n = 67), quantitative reverse transcriptase polymerase chain reaction (median and 95% confidence interval provided. P values calculated with two-sided Wilcoxon matched-pairs signed rank test; ALDH1A3 P = 0.0026, all others P < 0.0001). d, e Representative immunostaining for ALDH3A1 (d) and ALDH3A2 (e) in an esophageal cross-section featuring an adenocarcinoma (bar indicates 5 mm). f Summary of ALDH3A1 and -3A2 immunostaining in cancer-adjacent squamous tissue (SqT, n = 75), Barrett’s metaplasia (BM, n = 14); Barrett’s dysplasia (BD, n = 12), and EAC (n = 571) drawn from nine UK hospitals. Mean ± SEM provided, Kruskall–Wallis test with Dunn’s correction **P < 0.01, ****P < 0.0001. Source data are provided in the Source Data file.

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