Fig. 4: Tissue decanal is diagnostic and correlates to exhaled decanal. | Nature Communications

Fig. 4: Tissue decanal is diagnostic and correlates to exhaled decanal.

From: Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma

Fig. 4

a Receiver operating characteristic curve for EAC detection using a random forests multivariable model based on the indicated tissue aldehydes, measured by UPLC-MS/MS. b–g Comparison of tissue and exhaled butanal and decanal. b, e The receiver operating characteristic curve based on tissue butanal (b) or decanal (e) concentrations as a single biomarker (UPLC-MS/MS cohort). c, f Correlation of EAC tissue butanal (c) and decanal (f) concentration to the paired exhaled breath concentration (data from Markar et al.6). P values calculated with a two-tailed Spearman test. d, g Gas-phase concentrations of butanal (d) and decanal (g) in the headspace of healthy squamous (SqN, n = 24) and esophageal adenocarcinoma (EAC, n = 25) samples measured by proton transfer reaction time-of-flight mass spectrometry. Mean ± SEM provided with two-tailed Mann–Whitney U test. Source data are provided in the Source Data file.

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