Fig. 3: Common biological processes can be identified in tolerant subpopulations of distinct cell lines emerging from different treatments. | Nature Communications

Fig. 3: Common biological processes can be identified in tolerant subpopulations of distinct cell lines emerging from different treatments.

From: Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer

Fig. 3

a UMAP representation of cells in four models of drug tolerance. Cells are colored by days of treatment (left panels) and clusters (right panels). b Enrichment analysis for gene relations to GO BPs, KEGG pathways, or hallmark gene sets (MSigDB Collections) is shown for top markers of tolerant clusters (P < 0.05). Gene sets appearing highly significant at least in three out of four different treatments and with P > 10−4 in any of the clusters of untreated cells are shown. c Enrichment analysis for gene sets associated with chemical and genetic perturbations (CGPs). Gene sets that appear highly significant at least in three out of four different treatments are shown. In b and c, data represents right tail P values, two-sided binomial statistical test, adjusted for multiple testing using Benjamini–Hochberg FDR method. Terms discussed in the text are indicated by asteriscks.

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