Fig. 4: Scope of the reaction and product derivatization.
From: Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes
a The catalytic asymmetric synthesis of α-chiral BCPs displays a wide substrate scope and functional group tolerance, affording enantioenriched BCP products in high yields and enantioselectivities. b The aldehyde product can be derivatized to a range of other high-value chiral BCP building blocks. The absolute stereochemistry of 12 was assigned by comparison of supercritical fluid chromatography (SFC) data of a derivative with its enantiomer30; other products were assigned by analogy. See Supplementary Information, Section 3.2.2 for details. TEMPO = (2,2,6,6-tetramethylpiperidin-1-yl)oxyl; BAIB = PhI(OAc)2; DCE = 1,2-dichloroethane.
